Most men think about the topic of fertility way too late. Yet it is now known that by 2050 most men will have a sperm count of zero. Here are some things you need to be aware of when it comes to male fertility. Thread🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice. It’s George. For the last 70 years, fertility rates have decreased worldwide with a total over 50% decline overall. Right now it is estimated that at least 25 percent of couples
Spermatogenesis begins with spermatogonia ( stem cells located along the basement membrane of the seminiferous tubules). There are two main types: Type A (which divide mitotically to maintain the stem cell population) and Type B (which differentiate to continue the process).
Now, spermatogenesis is driven by 3 main hormones of the hypothalamic-pituitary-gonadal (HPG) axis: testosterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Here are some more details on this: -Hypothalamus, releases gonadotropin-releasing hormone (GnRH)
Now let’s mention some basic tests that you can get done in case you are wondering about your fertility status: -Semen analysis (which at sperm count, motility and morphology) -Total testosterone -Free testosterone -SHBG -Follicle-stimulating hormone (FSH) -Luteinizing hormone
Moving on to the common and main factors that negatively affect male fertility. Number 1: Herbicide and pesticide exposure (mainly glyphosate). In general some of the worst fertility disrupters are organochlorine compounds such as chlorinated pesticides plus organophosphate
Number 2: Polyester underwear. These are quite common, but polyester literally is a contraceptive. https://pubmed.ncbi.nlm.nih.go... Throw them out the window and get some cotton ones.
Number 3: Xenoestrogens overall (whether we are talking about plastics, parabens or mycotoxins). Besides avoiding: -Consuming grains, coffee and nuts/seeds that where shipped from God knows were very often and will 100% have mycotoxins in them -Ethanolamine compounds (cocamide
You can aid in their detoxification through: -Kefir/certain probiotics -Sunlight -Quercetin -Tualang honey -Cold pressed blackseed oil -Propolis -Green tea -Ginkgo -Aloe vera -Naringin -Kimchi -Cistanche -Fat soluble vitamins -Taurine -Sweating
Number 4: Being overweight. https://pmc.ncbi.nlm.nih.gov/a... *This is a problem so big all the way to even berberine (but also GLP-1 receptor agonists) overall shown now that it can help with male fertility. https://pmc.ncbi.nlm.nih.gov/a...
Number 5: Poor sleep quality. In order to understand how bad chronic lack of sleep is for male fertility, it leads to men having smaller balls. This isn't a joke. https://pmc.ncbi.nlm.nih.gov/a... https://pmc.ncbi.nlm.nih.gov/a...
If you are struggling with sleep issues, read this: https://x.com/Helios_Movement/...
Number 6: Steroid abuse / use without medical supervision. This is quite simple to understand since a negative feedback loop is created where exogenous testosterone inhibits GnRH and LH release for example.
Number 7: Not getting enough of the following nutrients whose deficiencies are shown to lead to reduced sperm count and motility: -B12 -Retinol -Choline -Bioavailable protein -Selenium -ZInc -Vitamin E -Vitamin D -B9 -Vitamin C https://pmc.ncbi.nlm.nih.gov/a...
Number 8: Statins. "What?". Yeah, coenzyme Q10 helps sperm movement and low levels are linked to decreased motility. https://pmc.ncbi.nlm.nih.gov/a...
Number 9: Lots of oxidative stress. This is a big topic so go and read this: https://x.com/Helios_Movement/...
Number 10: Chilling with your laptop on top of your balls or having your phone in your pocket 24/7. https://pmc.ncbi.nlm.nih.gov/a...
Number 11: Tight underwear and/or hot environments such as the sauna. This one is also quite simple since spermatogenesis requires 2-4°C below body temperature and heat stress disrupts meiosis and spermiogenesis via HSP70 and oxidative stress. Now if you want to use the sauna
Number 12: Smoking weed. https://www.nature.com/article...
Number 13: Finasteride. https://pubmed.ncbi.nlm.nih.go...
Number 14: Not taking into consideration certain MTHFR gene variants such as C677T. https://pubmed.ncbi.nlm.nih.go...
Number 15: Hormonal issues such as low testosterone. Get your free testosterone guide here: https://fitandball.gumroad.com...
Now let's move on top tools you can use. Number 1: Anything that can upregulate StAR such as: -Chrysin rich food such as quality raw honey -COX-2 inhibitors such as glycine, vitamin E, cistanche and apigenin rich foods such as chamomile -Things that can reduce DAX-1 such as
Number 2: Lactobacillus Reuteri. https://pmc.ncbi.nlm.nih.gov/a... Number 3: High quality maca. https://pubmed.ncbi.nlm.nih.go... https://pubmed.ncbi.nlm.nih.go...
Number 4: Acetyl L carnitine Number 5: CoQ10 Number 6: Creatine Number 7: Royal jelly Number 8: Shilajit Number 9: Taurine Number 10: Ginger Number 11: Astragalus Number 12: Cistanche https://www.sciencedirect.com/... https://sciencedirect.com/scie... https://sciencedirect.com/scie...
That was pretty much it. I hope that you found something useful inside of this thread. If you did make sure to leave a like/RT to spread the word. https://x.com/Helios_Movement/...