Published: March 25, 2025
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I take 2.5 mg of Cialis daily. Not for erections, but for longevity. Here’s what the science says about Cialis and lifespan extension… And why it’s not the reason behind my 3 hour long titanic nighttime erections. 🧵

0/ It sounds wild, but low-dose Cialis (tadalafil) and Viagra (sildenafil) are both drawing attention for longevity benefits. Recent clinical evidence indicates the use of either correlates to longer survival in men, in addition to their potential for heart health, metabolism,

Image in tweet by Bryan Johnson

1/ My nighttime erections are better than the average 18 year old, but Cialis is unlikely to play a meaningful role in them or even my sexual function. While it’s true that daily low-dose Cialis (2.5–5 mg) can help men with erectile dysfunction (ED) or benign prostatic

Image in tweet by Bryan Johnson

2/ Here is why you may consider taking Cialis Cialis’s effects on blood vessels might benefit many organs. It boosts nitric oxide (NO), relaxing arteries. Enabling better circulation, organ blood flow, and a bit lower blood pressure. Basically helping to keep your blood

Image in tweet by Bryan Johnson

3/ Cialis can improve your metabolism, blood sugar control and can help increase fat burning. Daily Cialis might improve how our bodies handle sugar. In a 2022 trial with diabetic men, 5 mg/day modestly lowered HbA1c (blood sugar marker) over 6 months​, Suggesting better insulin

Image in tweet by Bryan Johnson

4/ Cialis reduced chronic inflammation, a major driver of aging Termed “inflammaging”, chronic inflammation speeds aging. In a small study, men on daily Cialis for 6 months saw their elevated inflammatory markers (e.g. IL-6) drop back to normal​A calmer immune system = a

Image in tweet by Bryan Johnson

5/ Cialis can boost your brain Better blood flow might aid cognitive functions too, especially as we get older. In a small trial, older men taking daily Cialis improved on cognitive tests of attention and processing speed​. Even their brainwave patterns (EEG) got sharper,

Image in tweet by Bryan Johnson

6/ Long term Cialis use is generally safe in men, but comes with some possible side effects Tadalafil is a prescription drug. Common side effects at low doses: headache, flushing, nasal congestion, or heartburn – usually mild. It's considered safe for long-term use in many men

7/ Never mix Cialis (or any ED pill) with nitrate heart meds (e.g. nitroglycerin)​ That combo can cause a dangerous blood pressure crash. Also be careful if you're on multiple BP meds or have very low BP. Always consult your doctor first. A study comparing 55,777 men treated

Image in tweet by Bryan Johnson

@bryan_johnson 1) Why not take Nitric oxide tablets instead 2) Although we can trust your findings we not sure we can trust studies anymore unless funding is revealed

@bryan_johnson You would think that ALL diabetics would be automatically prescribed because they have bad circulation issues. Is that happening?

@bryan_johnson Kudos to you for citing scientific research unlike many of your media critics

@bryan_johnson Persistent long term use is most definitely bad for the heart. How much is Lilly paying you for this?

@bryan_johnson the study cannot make such a claim. and if that's the case, why not just go on a blood pressure drug?

@bryan_johnson Copper does this too. Most people are deficient because they don’t get enough from their diet.

@bryan_johnson Does Cialis have the same effects as citrulline or does it even make sense to use both?

@bryan_johnson Is it not unethical to recommend prescription drugs. Esp as you are not a qualified doctor????

@bryan_johnson doesn’t L-carnitine / L-arginine work the same

@bryan_johnson Most of you have already done irrevocable damage to your penile capillaries by middle age.

@bryan_johnson Take Beets instead of pharma compounds

@bryan_johnson Sex is the drug of longevity, not the chemical compound that gives you bonners

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