Published: May 13, 2025
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A Forgotten Antibiotic Just Shook Up the Lyme Disease Debate In a pair of new studies, one overlooked drug eliminated Lyme bacteria at doses 100x lower than standard antibiotics—without wrecking the gut microbiome. Even more surprising? It might prevent infection entirely. And

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Scientists may be closing in on two major advances in the fight against Lyme disease: an overlooked antibiotic that eliminates the infection at exceptionally low doses and new insights into why symptoms often persist long after treatment. https://www.theepochtimes.com/...

In a pair of studies published recently in Science Translational Medicine, scientists showed that piperacillin—a Food and Drug Administration-approved antibiotic—cleared Lyme infections in mice at doses up to 100 times lower than those of doxycycline, the current first-line

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“What was remarkable to us was how well piperacillin worked at really low doses,” Brandon L. Jutras, a professor in the microbiology-immunology department at Northwestern University Feinberg School of Medicine and lead researcher, told The Epoch Times. “We don’t need to provide

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A More Targeted Approach Lyme disease is an infectious illness that is spread to people through the bites of infected black-legged ticks and can lead to neurological and heart complications if untreated. Piperacillin works by interfering with the unique way Borrelia

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Currently, piperacillin is used to treat pneumonia and urinary tract infections and is not approved for use against Lyme disease in humans. Beyond treatment, the researchers also see promise in piperacillin as a potential preventive measure. The idea is that one dose, received

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Jutras noted that while the findings make piperacillin a promising option, it must first be tested and proven effective in human trials before physicians can prescribe it. Some experts also caution that any antibiotic—even at low doses—can contribute to antibiotic resistance.

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Why Lyme Symptoms Persist Lyme disease is now the most common vector-borne disease in the United States, with the Centers for Disease Control and Prevention estimating that approximately 500,000 Americans are diagnosed and treated each year. Unlike most infections, where the

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Holistic Approaches for Prevention To help reduce the risk of persistent symptoms, many doctors who specialize in Lyme treatment take a holistic approach to prevention and recovery. By lowering the number of lingering pathogens and supporting immune function, these strategies

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Early symptoms of Lyme disease, occurring 3 to 30 days after exposure, include: • Bull’s-eye rash (erythema migrans) • Fever, chills, or fatigue • Muscle aches and joint pain • Swollen lymph nodes Later symptoms, which may occur weeks to months after infection, include: •

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