*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice* Now it’s quite common to think that the skin is this very simple and almost purely aesthetic part of the body when in reality it is quite fascinating and complex. So let’s begin

We have: 1. The epidermis (the outermost layer of the skin). The epidermis is an avascular (lacking blood vessels) epithelium that serves as a protective barrier and varies in thickness depending on the part of the body (it’s thicker in your palms for example, compared to the

2. The dermis (the middle layer of the skin/the primary structural layer). The dermis is a thick, vascular connective tissue layer that sits beneath the epidermis and is the layer that provides structural support, elasticity and nourishment to the epidermis. It contains blood

3. The hypodermis (the innermost layer of the skin (some do not consider as part of the skin)). The hypodermis, also known as the subcutaneous layer, sits beneath the dermis and is a layer of mainly adipocytes whose primary role is to store triglycerides, provide thermal

Let’s talk about the skin microbiome. This term refers to the diverse community of microorganisms that form a complex ecosystem on the skin’s surface and within its layers such as the hair follicles and sweat glands. So this ecosystem hosts a variety of bacteria, some

Now here’s a practical example when it comes to why the things that were just mentioned are worth knowing. Each skin-related condition affects the skin’s layers differently. Psoriasis and eczema for example are epidermal disorders and acne is primarily a dermal disorder. So

Now let’s dive in the causes and mechanisms behind skin issues like acne, psoriasis, and eczema (all disrupt the skin’s anatomy, regeneration, and microbiome, often involving inflammation, barrier dysfunction, and microbial dysbiosis). 1. Acne Main causes: -Excess sebum: The

Biggest ROI steps/tools you can use for addressing acne: -Getting a hormonal panel done that includes androgens, cortisol, DHEA, DHEA-S, estrogens and IGF-1. Based on these results, you will know which diet suits you the best. If your IGF-1 for example, is very high, this makes

2. Psoriasis Main causes: -Immune dysregulation: Overactive T-cells (Th1/Th17) release cytokines (IL-17, IL-23, TNF-α), stimulating keratinocyte proliferation and the normal 28–30 day epidermal turnover cycle is reduced to 3–5 days, leading to an accumulation of immature

Biggest ROI steps/tools you can use for addressing psoriasis: -Stabilizing mast cells in case you have symptoms of histamine intolerance. -Relaxing, avoiding alcohol, stimulants, B5, zinc, selenium, C, B6 and magnesium deficiencies and in general anything that activates the

3. Eczema / atopic dermatitis Main causes: -Mutations in the FLG gene (encoding filaggrin, a protein in the stratum corneum) reduce the production of natural moisturizing factors (NMFs) and lipids (ceramides). And it’s unfortunately quite common with up to 50% of patients

Biggest ROI steps/tools you can use for addressing eczema: -Stabilizing mast cells in case you have symptoms of histamine intolerance. -Getting enough vitamin E, B5, zinc, selenium, C, B6 and magnesium. -Measuring your vitamin D levels (from 50% all the way up to 80% of

4. Rosacea Main causes: -Vascular dysfunction: Abnormalities in the dermal blood vessels lead to excessive vasodilation and increased blood flow, causing flushing and persistent redness. -Immune activation: Overactive innate immunity, particularly via toll-like receptor 2

Biggest ROI steps/tools you can use for addressing rosacea: -Topical ivermectin. -Stabilizing mast cells in case you have symptoms of histamine intolerance. -Stop smoking and using nicotine, both increase oxidative stress and VEGF expression. -Consider the following

5. Vitiligo Main causes: -Autoimmune issues: Cytotoxic T-cells and autoantibodies target melanocytes in the stratum basale driven by cytokines such as IFN-γ and TNF-α which trigger apoptosis of melanocytes. -Oxidative stress: Reactive oxygen species (ROS) accumulate in

6. Seborrheic dermatitis. Main causes: -Sebum overproduction. -Fungal overgrowth: Usually a malassezia yeast overgrowth and its byproducts trigger an immune response via TLRs. -Immune system dysregulation: Overactive innate immunity releases cytokines (IL-1, IL-8), recruiting

Biggest ROI steps/tools you can use for addressing it: -Getting a hormonal panel done that includes androgens, cortisol, estrogens and IGF-1. -Ketoconazole (it needs cycling every 2 weeks, you can use zinc pyrithione in between) -Get enough zinc, selenium, B1, B5 and vitamin

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@Helios_Movement Nice thread. Any advice for moles?

@cp38955 Nope.

@Helios_Movement Your thread is everybody's favorite! #TopUnroll https://threadreaderapp.com/th... 🙏🏼@ndelafourniere for 🥇unroll

@Helios_Movement Problems with acne? Try Meropenem 2 g IV over 3h q8h + Tobramycin 500 mg IV over 1h daily Run it for 8 weeks Accutane BTFO

@Helios_Movement Isn’t it strange that detoxing heavy metals often clears this up completely? …. Hmmm… all that distinction might have a root cause.

@Helios_Movement Just dropped a esoteric skin health nuke casually on a Sunday. There won’t be anything on X that beats this for a week.

@Helios_Movement Curious if you’ve explored Methylene Blue—we use it in a targeted soap and lotion, and a lot of our customers have seen real improvement with eczema and other inflammatory skin issues. 💧

@Helios_Movement I think I have dermatitis. Getting enough sunlight every day I’m catching the sunrise. Tried to fry it in the highest uv heat. Still there

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@Helios_Movement Thank you for this. My eldest son has chronic eczema, worsened in adulthood. Severe nut allergy and other foods. For me, I have milia. Across my chest, some under eye 😢. I’m thin, I have nutcracker syndrome. Eat high calorie foods to survive. How to stop milia forming? Thankyou

@Helios_Movement @grok Give me a short summary

@Helios_Movement What about couperose George- effective treatment for that? Lasers work soso. Thank you

@Helios_Movement Great information thank you

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@Helios_Movement Fantastic information

@Helios_Movement A very good thread full of useful information.