Published: August 22, 2025
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As a neurologist, I can’t ignore what I’ve been noticing, both professionally and socially. People are not the same as they were before the pandemic. The way they communicate, interact, and connect feels… different. I want to know if you’re feeling this too? 🧵

Across group chats, everyday conversations, and even professional exchanges, I see the same patterns: - Less humour - Less empathy or warmth - More abrupt, flat responses - Difficulty sustaining dialogue - A strange “hollowness” to interactions

This isn’t isolated to one demographic. If anything, it’s younger people who seem most affected. Their conversational agility, empathy, and humour all feel markedly reduced compared to just a few years ago. Conversations lack the depth and nuance I remember.

To anyone else, these shifts might pass unnoticed, chalked up to “changing culture” or “social media”. But when you study the brain for a living, these patterns line up alarmingly well with what SARS-CoV-2 does neurologically. Frontal-executive circuits are being compromised.

COVID affects multiple regions critical for social behaviour/comms: - Frontal Lobe: empathy/inhibition/social nuance - Temporal Lobe: language/word-finding/fluency - White Matter + Microvasculature: connectivity/processing speed - Neuroinflammation: fatigue/slowed cognition

Image in tweet by James Throt MBBS, MD, PhD, FRCPath
Image in tweet by James Throt MBBS, MD, PhD, FRCPath
Image in tweet by James Throt MBBS, MD, PhD, FRCPath
Image in tweet by James Throt MBBS, MD, PhD, FRCPath

Frontal lobe dysfunction in particular leads to blunted affect, low empathy & social disconnection Indifference to others’ suffering, reduced moral reasoning & impaired foresight will become increasingly common All the above seems diminished in so many day-to-day interactions

Image in tweet by James Throt MBBS, MD, PhD, FRCPath

If repeated infections cause cumulative injury, as mounting evidence suggests, then we should expect to see these subtle but widespread behavioural changes becoming the “new normal.” And that’s exactly what many of us are sensing.

Image in tweet by James Throt MBBS, MD, PhD, FRCPath
Image in tweet by James Throt MBBS, MD, PhD, FRCPath
Image in tweet by James Throt MBBS, MD, PhD, FRCPath
Image in tweet by James Throt MBBS, MD, PhD, FRCPath

The unsettling reality is this: if the majority are affected, the baseline shifts. What once would have stood out as neurologically abnormal now blends in, because nearly everyone is subtly compromised. This is reshaping how we think, feel, and interact on a societal scale.

We may be witnessing the early social consequences of mass neurological decline; not decades from now, but already, in real time. The changes are small, but unmistakable. And they align with what we know about the brain and COVID. END

“People aren’t any different now than before the pandemic” “People aren’t less empathetic today” “People aren’t behaving any differently” “People aren’t more aggressive” Alrighty then.

Image in tweet by James Throt MBBS, MD, PhD, FRCPath
Image in tweet by James Throt MBBS, MD, PhD, FRCPath
Image in tweet by James Throt MBBS, MD, PhD, FRCPath
Image in tweet by James Throt MBBS, MD, PhD, FRCPath

People really love to rewrite history. Schools began phased return June 2020, with all back by Sept. ‘Eat Out to Help Out’ was Aug 2020, people were literally encouraged into restaurants. Nightclubs reopened July 19th 2021. Hardly the endless, oppressive lockdown cited here.

The comments here are a cesspit of denial, minimisation, antivax tropes, lockdown hyperbole, evidence dismissal & disinformation Above all, they show an unwillingness to accept that a virus proven to damage the frontal lobe might explain symptoms of frontal lobe damage No hope

For the fallacies being spouted about lockdowns, children & their recent developmental/behavioural issues, please read this thread. It saves me having to address every nonsense reply. My god, if ever there was proof of cognitive decline in 2025, the comments here provide it.

Actually, this entire thread is unequivocally wrong. Proof of SARS-CoV-2 damaging the frontal lobe would not lead to presentations of frontal lobe dysfunction. It’s far more likely to be attributed to smart phones (invented 2007)/social media (2006)/a few months of lockdown /s

Important clarification: aggression, poor impulse control & antisocial behaviour trending today did not appear immediately post-lockdowns in 2021–22 These changes emerged more recently, consistent w/cumulative neurological impact from repeat infections, not short-term isolation.

@JamesThrot I think also the lockdowns contributed to it, a bunch of people pretty much acquired social anxiety, agoraphobia and then there are some others that emerged from quarantine with severe anti social behaviours, increased aggression which leads to rage and poor impulse control.

@influenya Lockdowns were brief in many countries and largely liberal. The patterns you describe; rage, poor impulse control, antisocial behaviour… align closely with frontal-executive dysfunction from repeated SARS-CoV-2 infections, not short-term isolation.

@JamesThrot Yes. It changed everyone. It was a global threat to us all. The only way to combat it was isolation. Forced isolation for a significant amount of time would have major effects on anyone, and everyone went through it. Worldwide trauma tends to have long lasting effects.

@Artfulgiant256 Yes, covid was a global threat. But in many countries, isolation was brief & not as severe as often portrayed The neurological impacts we’re observing go beyond what short-term social isolation alone could produce, they correlate w/repeat viral infection/documented brain damage.

@JamesThrot My guess is that it’s primarily burnout, cultural change, and social media.

@henrybenedict_X Personal guesswork doesn’t trump peer-reviewed science. Repeated COVID infections cause measurable frontal-executive damage. Burnout or social media trends don’t physically impair attention, working memory, or moral reasoning.

@JamesThrot Lockdowns did this

@TrishtheSkeptic Yes it’s definitely not the neurotropic virus which everyone is being infected with 1-2x per year, with which peer reviewed science proves damage to the frontal-executive circuits. No, it’s the lockdowns, which lasted mere months in many countries and were quite liberal.

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