STATISTICAL MEDICINE DUJOUR A lot of bro-scientists obsess over VO2 max as predictive RF; it is largely so (particularly when low). Calcium score for people as they age is the most predictive one WHEN it is 0 or very high (>1k). You are "as old as your arteries". h/t @DrDamluji
2/If your CAC is bad, THEN you must compensate w/a high VO2 max, which offsets partially the risk of a CV event. If CAC is 0 then VO2 max is largely uninformative outside of pathologies. Many top athletes still experience heart attacks unless CAC is 0.
3/By their 70s only 5% of males have a negative CAC. So one can see the connection with the force of mortality: the drop is nearly linear to age. It is ~ aging.
4/Also beware: VO2 max is not ratiometric; you need less relative O2 for the same output as your size grows; it scales at the power betw 2/3 & 3/4. By Klieber's law, large bodies (elephants) need less energy than smaller ones. So a 200 lb person with VO2max 45 ~equiv 55 for
@nntaleb @DrDamluji VO₂ max is training vanity. The calcium score is a survival reality. You don't hack the entropy.
@nntaleb @DrDamluji how frequently should one take calcium score tests at ~50+? every 5 years?
@nntaleb @DrDamluji Is there a meaningful relationship between VO2 max and calcium score?
@nntaleb @DrDamluji Whats the best way to keep healthy CAC levels as you age?
@nntaleb @DrDamluji Predictive RF? What's that?
@nntaleb @DrDamluji Should you take the CAC test once on statins, since they will raise the number anyway, possibly causing unnecessary concern with the patient?
@nntaleb @DrDamluji I would bet that having a higher VO2 max would help an elderly person survive pneumonia, a common cause of death.
@nntaleb @DrDamluji @grok can you explain this entire thread to me like I’m not smart
PARADISE DOES NOT LOOK LIKE PARADISE Spent a month in Campania before moving to the US for school. Everybody then wanted to come to America, esp. my Italian friends. Loved the NJ turnpike w/the vitality in the air. Scenery is for retirees with easels --boring w/o the energy.
Success is only found through failure. You have to be able to manage failure to find the success.
I'm one of the few people who have been close to important voices on the Zionist and pro-Palestinian side. So I am in a unique position to make some observations. There is no shortage of in-fighting and cruelty on both. And one thing I noticed is how much kinder and more
Homegrown arugula & figs with homemade mozzarella & some olive oil & salt.
