Published: September 16, 2025
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Irregular sleep is just as bad as getting less sleep. Both are linked to the risk of 172 diseases. 42 showed more than doubled risk with bad sleep. Almost half of these diseases were associated with irregular sleep. Things like inconsistent bed times, late sleep hours, and

Image in tweet by Bryan Johnson

0/ The study: 88,461 adults with both wearable and self-reported sleep data were studied over an average 6.8-year follow-up. The goal was to reassess sleep-related disease risks and identify the sleep parameters driving the risk. The study analyzed circadian rhythm consistency

Image in tweet by Bryan Johnson

1/ This shows wearable data is useful for accurately defining sleep parameters and disease risk, correcting previous misconceptions from self-reported data that often overemphasize sleep duration while neglecting other vital parameters such as bedtime and consistency.

@bryan_johnson Cute problem to solve if ur wealthy Imagine not having a choice My least favorite thing about ur message

@bryan_johnson @grok tell me about Kant's sleep schedule

@bryan_johnson I do think there is too much focus on amount of sleep and less on the importance of the quality of sleep

@bryan_johnson What if the problem is not irregular sleep but the fact that when the sleep is irregular people those days drink alcohol, eat food before sleep because of parties etc?

@bryan_johnson The most powerful hack to fix this isn't a strict bedtime, it's a non-negotiable wake-up time. Wake up at the same time every single day—even on weekends. Your body will naturally learn when to get tired, anchoring your entire circadian rhythm.

@bryan_johnson @grok, please conduct a scientific deep dive into this topic and propose possible solutions for improving irregular sleep for different age groups.

@bryan_johnson I can’t sleep.

@bryan_johnson You're telling me that the working pattern of Conductors and Engineers in the Rail industry is wildy unhealthy? Go on. I'm certain there is a class action lawyer salivating right now.

@bryan_johnson I’ve struggled with sleep consistency since I was a young little shit, & i’ve nearly lost hope of finding a true sleep schedule. i’ve been managing ‘fine’ so far but i’m working on it

@bryan_johnson how do we solve for this and still raise kids?

@bryan_johnson Ben Franklin was a biphasic sleeper and lived to 84 in the 1700s. First sleep, second sleep was the normal schedule before the Industrial revolution. I like a little siesta and do my best thinking at night

Image in tweet by Bryan Johnson

@bryan_johnson Well that sounds scary. Anyway…. Going to finish my third glass of wine and head to bed.

@bryan_johnson Worrying about sleep because I know it's important makes my sleep problems worse.

@bryan_johnson There’s no hope for us extreme shift workers then 😭

@bryan_johnson I have suffered of migraines for many years now. I learned that irregular sleep is one of the key factors that triggers them.

@bryan_johnson People have lost sight of just how important their circadian rhythm is. Things like artificial lights, cheap dopamine, and stress are keeping us up later than the sun. If you want to feel better overall and get better sleep, start getting ready for bed at sundown.

@bryan_johnson Stress, scrolling your phone, or watching TV in bed trains your brain to see your bed as anything but a sleep sanctuary. As Rollo May said, “The human dilemma is that which arises out of a man's capacity to experience himself as both subject and object.” Our habits-scrolling late

@bryan_johnson Bro you can be right but work is also important as much as our sleep

@bryan_johnson laughs in devops

@bryan_johnson How did you manage this when parenting little children?

@bryan_johnson how to fix this: simply sleep more hours!!

@bryan_johnson been solely focused on improving sleep and quality during this cut phase

@bryan_johnson Correlation is not causation.

@bryan_johnson How much of this is just the correlation between irregular sleep patterns and stress/overall bad health?

@bryan_johnson Yikes. Sleep matters a lot yo.

@bryan_johnson sleep is leverage on life expectancy

@bryan_johnson I feel I get more sleep if get a prostate massage

@bryan_johnson Do you use cpap machine ?

@bryan_johnson Reading this while Jet-lagged on an international flight to a distant continent. Thanks🫠

@bryan_johnson Did they control for pre-existing conditions?

@bryan_johnson Interesting

@bryan_johnson I wonder whether it's more harmful to get 8 hours each day but irregularly or 6 hours a day but consistently

@bryan_johnson Bro I’m not reading all that I feel you tho

@bryan_johnson When you start: - Eating - Sleeping - Relaxing - And working At the same time every day, your body begins to release the associated hormones at the perfect times. You get hungry when you're supposed to be, you get sleepy when you're supposed to be, etc.

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