While growth hormone's role in muscle growth or performance is overrated, it might have some effects on body composition and recovery. Melatonin boosts GH by suppressing somatostatin, enabling GH release even during the day, independent of sleep. While exercise alone raises GH,

Neither melatonin supplementation (0.5 or 5.0 mg) nor resistance exercise had a significant effect on serum IGF-1 levels during the 2-hour study window That's because the rise of IGF-1 from growth hormone takes several hours - up to 8-24 hours Thus, it's biologically plausible

@siimland Melatonin shouldn’t even be OTC tbh

@siimland What about the implications of the endogenous production when talking exogenous?

@siimland melatonin will also suppress your gonadotropins lmao

@siimland Taking melatonin during the day or pre-gym seems like a bad idea lol

@siimland Nothing game-changing about this. An acute spike on GH that will not have a significant increases in muscle growth over time. Better to keep using melatonin to aid with sleep.

@siimland What brand do you take? It's been shown that many brands when measures are significantly higher than what is labeled...

@siimland Imagine popping a melatonin before a gym session though 😂

@siimland Melatonin at too high a dose flattens the good. Low is the way to go for full exposure of the good. And no one will have a clue what I am saying, but it is super cool. •

@siimland Interesting findings, Siim. The interplay between melatonin supplementation and growth hormone (GH) secretion is fascinating. While melatonin naturally influences sleep cycles, its role in potentiating GH release, especially in combination with exercise, merits further

@siimland What about side effects on the rest of the body's systems (and hormones)? Some people have SNPs that make melatonin supplementation problematic.

@siimland The timing here is clever as melatonin tricks body into releasing GH during the day when it normally wouldn't. Most people only think of melatonin for sleep, missing this daytime metabolic hack.

@siimland Melatonin, workout then sleep.

@siimland Interesting for sure.

@siimland Your internal clock, regulated by the Suprachiasmatic Nucleus (SCN), is synchronised to light exposure. - Light suppresses melatonin for alertness. - Darkness stimulates melatonin, promoting sleep. Morning light exposure resets rhythms, which is critical for shift workers and

@siimland Melatonin just went from sleep aid to performance hack. Fascinating.

@siimland The findings shared by @siimland highlight the intriguing effects of melatonin on growth hormone (GH) levels, particularly when combined with resistance training.

@siimland Well thats cool!

@siimland https://x.com/i/grok/share/IEv...

@siimland @grok does this study suggest I should pop melatonin before the gym??

@siimland I think that you’re confusing insulin like growth factor with actual growth hormone, dipshit. They are two completely different hormones. Leave the endocrinology to the experts.

@siimland The picture you posted does not show what you are claiming. Try again.

@siimland Why do peole not just consume dried cranberries instead of taking a melatonin supplement

@siimland And sunlight is all you need to make your skin a melatonin factory

@siimland now do sustained GH, released GH has very little meaning; of course your body RELEASES the 'recovery hormone' when recovery is needed

@siimland This is a study from a small sample size in 2007, do we more up to date data? Systematic review?

@siimland But didn’t Scott Zimmerman’s research suggest that when exposed to stressors like exercise, melatonin levels can naturally rise alongside cortisol? Endogenous melatonin production?

@siimland Is this not risky for cancer?

@siimland Taking caffeine and beta alanine when i should have been taking melatonin

@siimland cool :) for how long did gh stay elevated?

@siimland So mg 5 melatonin is the new addition to pre-workout you saying....

@siimland That's interesting I take melatonin AFTER my night workout

@siimland That’s it?! 5mg 😂

@siimland I think one would be in the weightroom but groggy.

@siimland Small molecules, big signals. Melatonin looks underrated for GH optimization.