2/ And a big thank you to @emilylmullin @WIRED for a fantastic writeup on the study! With the psychedelic "trip" removed, we now have the central building block for many new psychoactive effects. Beauty, or insight, or wonder - new "emotions in a bottle." https://www.wired.com/story/a-...

3/ Why do different psychedelics feel so radically different from each other? 👽DMT: Aliens & elves ⏪Ibogaine: Memory replays 🎵DiPT: Pitch distortions ♾ 5-MeO-DMT: Infinite void 💭2C-E: Heavy introspection This diversity is the key.

4/ The differences between psychedelic effects imply a general biological mechanism for rendering mental states. We set out to identify that mechanism.

5/ If successful, psychiatry would gain for mental states what CRISPR gave genetics, what mRNA gave vaccines, and what CAR-T gave immunology: A programmable substrate.

6/ Our Osmanthus platform quantifies the patterns of neurotransmitter activity that correspond to each mental state. It uses reports from 70,000+ psychedelic experiences, biochemical data, and an ensemble of machine learning, stats, and semantic embedding models.

7/ Osmanthus paints a picture of a modular system by which different psychedelic drugs are eliciting different mental states: An access mechanism + accessible modules.

8/ So we developed MSD-001: a “psychedelic tofu" by itself, on which we'll build many psychoactive effects. It engages the access mechanism without any of the modules predicted to render the effects people think of as psychedelic - hallucinations, unity, etc. Bland by design.

9/ In a blinded, placebo-controlled human trial, MSD-001 showed: – No hallucinations – Less “psychedelic” than any known psychedelic on all 7 standard non-visual dimensions With the access mechanism isolated, we're now combining it with modular add-ons to render specific states.

10/ Today, only 3 human mental states are widely available by prescription: 1️⃣Focus (Adderall) 2️⃣Bliss (Vicodin) 3️⃣Contentment (Xanax) That’s a tiny slice of the 100+ mental states in the human spectrum (and those 3 are certainly not among the best). What about the rest?

11/ This trial was the beginning of the 98% of psychoactive drug classes that don’t yet exist. Psychiatry’s future: ID the mental state that is probable to be therapeutic for the diagnosis, then deliver that psychoactive state directly.

12/ Our first new “emotion in a bottle”: tranquil insightful beauty. An MSD-001 combo designed to reliably enhance aesthetic perception, without hallucinations. This state occasionally flickers in compounds like DOI, 2C-B, or mescaline. When people experience this effect, they

13/ Mental health is the largest unmet need in medicine and the foundation of literally everything humans do, from defense to energy to AI. Polarization, loneliness, addiction, overdose, suicide, incarceration - the measures of our society’s psychological health are all at

14/ If you want to help build the thing that psychedelics become - reply, DM, or reach us at info@mindstate.design.

@DillanDiNardo @grok good way to test for aleph harmonic qualia?

@DillanDiNardo If you could create MDMA without psychedelics effect and the afterdip. Would be a game changer in the world. Nr 1 sociable psychedelic out there, hence why so popular on festivals. IncreaseA your empathy, sense of connection. Sensing what others feel, and longing for connecting

@DillanDiNardo Hey @DillanDiNardo, have you ever taken macro doses of psychedelics or even heroic doses? If so, which ones? (It goes without saying that if you did, it would have been in a setting and location where it was perfectly legal.)

@DillanDiNardo So how people experience events can now be tailor made and inescapably biochemically imposed on them, if any person in the world is unethical enough to give this to someone without prescription and consent? Happy for the suffering this could alleviate. But even propaganda can

@DillanDiNardo The fuck. No one is gonna buy that shit because it’s processed. Leave nature alone.

@DillanDiNardo The thought of this on the open market kind of horrifies me. Would the health of a person self-medicating their emotional state be healthy? Also, this tech would be a wet dream to tyrannical state. Don't get me wrong, this tech seems cool as hell, but looks like it requires guide

@RadioRoscoe 100% agree. These will be physician-prescribed, and before approval will have extensive abuse liability assessments.

@DillanDiNardo Asking Grok to explain this post that showed up on my timeline : So they intend for it to be like a robot bartender that creates and makes drugs to order? Perhaps scanning the DNA, mental states, and biochemistry of each customer? -- More mood enhancers and safe mind expanding

@DillanDiNardo Sounds like governments will soon have the torture machine from 1984

@DillanDiNardo This is cool, but it is also creepy and you need to recognize that. Recommend you get a savvy marketing person to post.

@DillanDiNardo What are the possible side effects, kind of reminds me of a brave new world. not to be a buzzkill. I think it could be useful for designing therapeutic drugs however especially if you can do it clean.

@DillanDiNardo That’s not human experience. Human experience is moving around like a human, traveling, looking for the next place to cool off or eat or pee. Stop trying to make circuits more than c3po.

@DillanDiNardo Have you read Brave New World? You might want to

@DillanDiNardo These can serve as introductory instruments to elicit specific states, combined with learning self-prompting to induce these specific states, with the goal to learn to achieve it eventually without drugs, would be a healthy alternative to life long pill popping.

@DillanDiNardo Very interesting as a real product, could genuinely change the game for people on these meds, especially if it helps prevent deaths. The experiences/data you’ve used to train the model to recognize a specific branch of mental state should boost accuracy over time as the dataset

@DillanDiNardo @Claffertyshane : Pls investigate?

@DillanDiNardo This sounds so unreal, yet plausible enough to be believable. This will turn doctors into shamans, in a good way maybe. Also, where does one sign up?

@DillanDiNardo When experience becomes programmable the line between therapeutics and augmentation blurs and the market becomes as much existential as it is medical

@DillanDiNardo This is a fascinating evolution in neurotechnology! The idea of programming mental states raises intriguing questions—how do we ensure ethical usage, and what implications might this have for mental health treatment? How do you envision regulatory frameworks adapting to such

@DillanDiNardo So you are saying we all are actually living in a simulation

@DillanDiNardo Oh my friend - you’d love this then. Should make it 70,001… https://x.com/lordofthedrift/s...

@DillanDiNardo Amazing developments!

@DillanDiNardo Once these items become routine prescriptions, at what point do govts just introduce them to our water systems? Systems like a recipe for a passive docile population.