Published: October 1, 2025
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Treating COVID-19 with Medicinal Plants: Is It Even Conceivable? A Comprehensive Review

Image in tweet by polycultured

"Since these 10 herbs hold distinct bioactive compounds with significant properties in vitro & w/ remarkable benefits to human health, it is possible to prevent SARS-CoV-2 infection & reduce its symptomatic manifestations by consuming any of these plants" https://www.mdpi.com/1999-4915...

Ginkgo Biloba - "its GA and bioflavonoids can block SARS-CoV-2 3-chymotrypsin-like protease (3CLpro), as observed in inhibition kinetic studies and docking simulations [33]. In addition, GBE effectively inhibited SARS-CoV-2 3CLpro activity in in vitro experiments"

Curcumin - "Modelling studies showed that curcumin inhibits the S-protein-ACE2 interaction in two ways. Curcumin can either bind directly to the receptor binding domain of viral S-proteins or secure ACE2 receptors of the host cell."

Artemisia annua - "Based on docking analyses and among various compounds such as rutin, artemisinin interacts with the 3CLpro active binding sites with a good binding energy"

Nigella sativa - "carvacrol extracted from N. sativa can block ACE2 receptors, thus inhibiting the SARS-CoV-2 entry into the host cells... dithymoquinone presents a high binding affinity targeting SARS-CoV-2/ACE2 complexes"

Ginger - "A docking analysis study showed that 6-gingerol, 8-gingerol, and 10-gingerol are great inhibitors of the PLpro enzyme, which is essential for SARS-CoV-2 replication"

Rosemary - "the ability of rosemary extracts to either prevent the infection of the virus by inhibiting the S-protein-ACE2 complexes or block viral proliferation by inhibiting its main protease enzyme"

Dandelion - "compounds extracted with water from dandelions showed efficacy against spike proteins D614 and its different mutants... water extracts from roots displayed significant antiviral effects against SARS-CoV-2 and inhibited its viral activity"

Oregano - "the efficacy of essential oils extracted from oregano, specifically carvacrol, which constitutes the major component, in the disruption of the infection ability of SARS-CoV-2 and its entry into the host by binding to ACE2 receptors of the host and by LOX inhibition..."

"...which leads to less production of leukotrienes, which are important in the initiation and permanence of the cytokine storm (IL-1β, IL-6, IL-12, and TNF-α) induced by inflammatory responses"

Discussion: "We highlighted the main biological activities of these plants, which are closely related to disrupting the life cycle of SARS-CoV-2 particles. Interestingly, the considered plants had multiple factors in common"

Loads of new herbal antiviral studies are updated on our resource hub: https://www.polycultured.com/h...

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