@MaryanneDemasi @Kevin_McKernan @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques The primary source is Balzarolo et al. The authors show that “the response to m⁶A-methylated DNA is identical to unmethylated DNA.” Since bacteria lack CpG methylation, the response will be identical regardless of whether adenine is methylated. Nothing “hyper-stimulatory” here.

@luijsterburglab @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques How’s the Novo Nordisk Vaccine money at Leiden U? Why wouldn’t you answer our previous questions about many spikes come from the vaccine vs the virus? Still having trouble with Avo’s number? Grok is here to show how irrelevant you are… https://x.com/i/grok/share/Zha...

@Kevin_McKernan @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques The only reference for this claim is Balzarolo et al. I cite from their paper: “m6A is immunostimulatory in some motifs, but immunosuppressive in others,” and “The response to m6A-methylated DNA is identical to unmethylated DNA.” I rest my case.

@luijsterburglab @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques You got bagged. Your comment is a clear sign you didnt read the paper to see the CD69 signals. Keep digging that hole.

@Kevin_McKernan @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques Listen, buddy, if I want to talk to an AI bot, I don’t need a middleman — and especially not you.

@luijsterburglab @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques But you still wont acknowledge the paper you cited contains these facts about CD69 being differentially stimulated with m6A. Just deflect about how AI burned you. Got it.

@luijsterburglab @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques Why are you not addressing this figure from the paper? Cat got your tongue? Or are you going to focus on how AI could read this and interpret it, but you, a self proclaimed specialist in the field couldn't see it?

@Kevin_McKernan @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques Where does it show this is "hyper-stimulatory", as opposed to moderately stimulatory, or somewhat stimulatory?

@Kevin_McKernan @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques We've come full circle. The claim that adenine methylation is "hyper-stimulatory" is not supported by the data. Thus, an exaggeration in the title is usually a telltale sign of poor science (with the "hyper-stimulatory" title serving to mask it).

@luijsterburglab @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques Maybe practice those circles with your crayons.

@Kevin_McKernan @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques Where's the difference? Left is random; right is adenine methylated. The difference is sticking GATC in the middle, leading to a reduction, which is restored when A is methylated.

@Kevin_McKernan @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques For iNOS, the levels are even lower when A is methylated compared to random, meaning it's hypo-inflammatory! So, what's your point again?

@Kevin_McKernan @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques And if you have no further proof for "hyper-stimulatory" inflammation by adenine methylation, which was due to your misreading the figure above, then please correct the misleading and exaggerated preprint title you posted.

@luijsterburglab @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques There will be no correction as you’ve presented nothing to counter your complete and under gaff reading this paper and others.

@Kevin_McKernan @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques I'll paste it here again. The levels of iNOS transcript, a marker for inflammation, are reduced when A-methylated DNA is compared to random DNA. Therefore, any claim of "hyperinflammation" is false.

@luijsterburglab @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques Don’t make me break out the crayons for the low wattage beta academics.

@Kevin_McKernan @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques I wish you did!

@luijsterburglab @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques That’s polyA DNA which is also in the shot genius. But you ignored the P values in GmATC vs GATC is the exact control you claim is the same. You do know that the shots can decay cognition.. maybe get that checked.

@Kevin_McKernan @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques GATC is lower than poly(A:T). Thus, GATC is hypo-inflammatory. GmATC partially corrects this, but never exceeds it. Still, no hyper-inflammation.

@luijsterburglab @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques You are clueless to the fact that PolyA/T also hits RIGI and Pol3. The proper control for Process 1 (PCR) vs Process 2 (Dam methylated) is what you have been shown but still can’t Grok.

@luijsterburglab @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques Note the asterisk and P values. Still having a hard time?

@luijsterburglab @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques Other papers support this so pack it up. You lost.

@luijsterburglab @MaryanneDemasi @jeffreyatucker @TonyNikolic10 @ClareCraigPath @JesslovesMJK @dragonfishy @RWMaloneMD @weldeiry @Humanspective @DrEliDavid @kenjaques You were saying?