Immune related adverse events- an overview of the problem! 🔹>90% experience irAEs. Most common is rash🥵 and least is myocarditis ❤️🔥 #ACR2025 #rheumatology
Most irAEs occur in the first 6 months! Hepatitis & hypophysitis can occur later
Why do irAEs happen?
How do we mitigate irAEs? ? Early detection: we don't have biomarkers!😑 ⚖️ Stopping ICI or broad immunosuppression that can potentially affect anti-tumour immune response #ACR2025
An overview of the approach to define biomarkers for the most severe irAE ---> myocarditis ❤️🔥 What's in the? 🩸 What's in the tissue? 🫀 What correlates with severity? 📈 What is the target antigen? 🎯 #ACR2025
@PanktiMehta24 Nice COI 😂 CART collaboration trial/paper when
Beyond CAR-T @MaxKonigMD We heard about the cons of CAR-T therapy, what is the potential solution? BiTEs? #ACR25 #rheumatology
