🧵 Post 1 | Sjögren’s PNS Guidelines — #ACR25 Highlights 🧠 Peripheral Nervous System involvement = common but under-recognized in Sjögren’s 🧩 Spectrum: Mono | Poly | Autonomic neuropathies 📘 Unified Rheum–Neuro terminology (Arthritis Rheumatol 2025) 🩺 Diagnosis =
Orofacial Systemic Sclerosis [Andrew Leask] #ACR2025 #SSc #Rheumatology #MedTwitter & Dental Care 🦷🪥
🫀PAH in CTD other than Scleroderma is not uncommon 👉CTD PAH is✅ largest group of associated PAH 👉👉17% SLE patients have PAH , more than MCTD . #ACR25 #ACRheum #ACRambassador
#Neurosarcoidosis: affects CNS/PNS. 🔍Dx: MRI w/ gadolinium key; CSF ⬆️ protein, lymphocytes, oligoclonal bands 🧪New markers: ⬆️CD4/CD8 ratio, IL-6, sIL-2R. 💊Early steroids ± DMARD/anti-TNF; long-term immunosuppression common #ACR25
🧬 ACR25 Clinical Pearl – Dr. Janet Pope: Sjögren’s & Lymphoma Risk •💠 Lymphoma risk in Sjögren’s: ~5–10% lifetime. •🚫 Routine screening in all patients = wasteful. Focus on high-risk only. •⚠️ High-risk predictors (≥3 = ~40% risk; all 7 = ~100%) • Persistent parotid
