They used a form of vitamin B3 called niacinamide, which is a derivative of niacin or nicotinic acid - the standard form we get from food. This form of B3 gets more efficiently converted into a molecule called NAD+, which is where much of vitamin B3's activity lies. People

Niacinamide (B3) substantially reduced the presence of age spots in the skin. They continued to disappear with time, maxing out at 12 weeks. (3/8)

Niacinmiade reduces wrinkles, too. Again, the biggest effect was after 12 weeks, with a marked reduction in wrinkles. (4/8)

Skin yellowing was improved with niacinamide. Another relatively common sign of skin aging, which happens when proteins in the skin become glycated (AGEs). Niacinamide stops it. (5/8)

Skin elasticity is also typically worsened with age as a result of loss of collagen and elastin proteins. Niacinamide was shown to improve this property as well. (6/8)

They noted that the production of glycosaminoglycans were 2-3X higher in aged skin cells. These are important structural components of the skin but become overproduced as the skin ages and becomes damaged. Niacinamide was able to reduce this process in cells. (7/8)

Niacinamide works by several different mechanisms to counteract aging in the skin, it's an absolute powerhouse. Supplying sufficient NAD+ is the key here. ➜ Direct antibacterial / antifungal ➜ Antioxidant effects - preventing cell damage / death by supporting NADPH

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@Outdoctrination Wait. Where can we get 5% niacinamide to use in a pea sized amount for our face? 😂

@Outdoctrination It's exciting to see the potential implications of vitamin B3 on skin aging. However, before drawing conclusions, it's essential to evaluate the study's scope, methodology, and sample size. Are the results peer-reviewed, and have they been replicated? The promise of reversing all

@Outdoctrination Niacinamide definitely helps with skin texture, spots, and overall look, but calling it a full reversal of aging is an exaggeration. It’s like steady improvements over months rather than a total reset.

@Outdoctrination Procter & Gamble Company... .no conflict of interest then?

@pilatesfitness other studies have confirmed this not done by them. it's just the way it is, the money needs to come from somewhere

@Outdoctrination 12 weeks and only 5% reduction in age spits and wrinkle length. Why is this a big deal? Is that even noticeable with the naked eye?

@Outdoctrination I have recently seen a study showing B3 (niacinamide) helps with psoriasis, eczema and fights some forms of skin cancer.

@Outdoctrination Take 15-20% Niacinamide Serum (there are some Korean brands) together with 15% Vitamin C Serum and after 3-4 weeks you will be astonished.

@Outdoctrination @grok True or false: Niacinamide and nicotinamide refer to the same compound, which is a form of vitamin B3.

@Outdoctrination Your thread is creating a buzz! #TopUnroll https://threadreaderapp.com/th... 🙏🏼@NeuroCoachMic for 🥇unroll

@Outdoctrination @threadreaderapp unroll

@Outdoctrination Can you talk about how to reverse glycated skin?

@RexSteps niacinamide does it!

@Outdoctrination I get massive hot flashes after taking niacinamide for a week or so. Apparently a common issue

@julebrus_kongen you might be thinking of niacin

@Outdoctrination The findings regarding vitamin B3 (niacinamide) are indeed compelling, highlighting its potential role in skin rejuvenation.

@Outdoctrination Every single skincare product has niacinamide lol

@Outdoctrination Scientologists use it for detoxification.

@Outdoctrination Another excellent thread!

@Outdoctrination @grok is this true

@Outdoctrination I'm