This was a small pilot study in women using amphetamines. This, to nobody's surprise, is associated with a high prevalence of depression. Creatine was the tool of choice here mainly because depressed individuals often have low brain creatine stores. This is especially true in

11 women were enrolled, those with other conditions or who were already on depression treatments were excluded. They were given 5g of creatine monohydrate per day for 8 weeks.

The participants had dramatic and rapid drops in depression ratings. After just one week of initiating treatment, depression scores dropped by ~35%. They continued to plummet, eventually dropping by 63% before creatine was discontinued. After which, symptoms crept back up, but

The drop in anxiety scores was even more pronounced. Within a week anxiety scores were down over 50%. After 7, down over 95%. Simply stunning.

Now, there's fair criticism here. It was a small study, no placebo, and in meth users. However, creatine's antidepressant/anti-anxiety effects are not a one off. Other studies like this have shown similar results - 5g a day dropped depression scored by ~50% and anxiety by a

Other studies have confirmed this as well. In the thread below, I cover the mechanisms of how creatine improves the health of the brain, as well as some of the other studies on mental / cognitive health.

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